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Large common fragile site genes and cancer

✍ Scribed by David I. Smith; Sarah McAvoy; Yu Zhu; Damon S. Perez

Book ID
113900293
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
478 KB
Volume
17
Category
Article
ISSN
1044-579X

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## Abstract Common fragile sites (CFS) are large, genomically unstable regions, which are hot‐spots for deletions and other alterations, especially in cancer cells. Several have been shown to contain genes that span large genomic regions, such as __FHIT__ (1.5 Mb), __WWOX__ (1.0 Mb), __GRID2__ (1.3