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Alterations in the common fragile site gene Parkin in ovarian and other cancers

✍ Scribed by Denison, Stacy R; Wang, Fang; Becker, Nicole A; Schüle, Birgitt; Kock, Norman; Phillips, Leslie A; Klein, Christine; Smith, David I

Book ID
110068156
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
220 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Common fragile sites (CFS) are large, genomically unstable regions, which are hot‐spots for deletions and other alterations, especially in cancer cells. Several have been shown to contain genes that span large genomic regions, such as __FHIT__ (1.5 Mb), __WWOX__ (1.0 Mb), __GRID2__ (1.3