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Characterization of the common fragile site FRA9E and its potential role in ovarian cancer

✍ Scribed by Callahan, Gwen; Denison, Stacy R; Phillips, Leslie A; Shridhar, Viji; Smith, David I

Book ID
110067292
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
491 KB
Volume
22
Category
Article
ISSN
0950-9232

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## Abstract Characterization of FRA6E (6q26), the third most frequently observed common fragile site (CFS) in the human population, determined that aphidicolin‐induced instability at FRA6E extends over a very large region (3.6 Mb). Sequence analysis identified eight genes (__IGF2R__, __SLC22A1__, _

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Recently, several common fragile sites (CFSs) have been cloned and characterized, including the two most frequently observed in the human population, FRA3B and FRA16D. In addition to their high frequency of breakage, FRA3B and FRA16D colocalize with genes crossing large regions of breakage. At FRA3B

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