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Common fragile sites, extremely large genes, neural development and cancer

✍ Scribed by David I Smith; Yu Zhu; Sarah McAvoy; Robert Kuhn

Book ID
116333881
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
185 KB
Volume
232
Category
Article
ISSN
0304-3835

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## Abstract Common fragile sites (CFS) are large, genomically unstable regions, which are hot‐spots for deletions and other alterations, especially in cancer cells. Several have been shown to contain genes that span large genomic regions, such as __FHIT__ (1.5 Mb), __WWOX__ (1.0 Mb), __GRID2__ (1.3