Lanthanides—the future drugs?

✍ Scribed by Kui Wang; Rongchang Li; Yi Cheng; Bing Zhu

• Book ID: 104111953
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 269 KB
• Volume: 190-192
• Category: Article
• ISSN: 0010-8545
• DOI: 10.1016/s0010-8545(99)00072-7

✦ Synopsis

Previous studies on the therapeutical application of lanthanides are critically reviewed. The difference in toxicity/activity between Ln and heavy metals is discussed on the basis of their similarity to calcium ion and deviation from it. Experimental results are summarized to show that the appropriate uses of the regulatory effects of Ln would be useful in therapeutical application. The perforation of cell membrane and apoptosis induced by Ln as well as their influence on ROS mediated oxidative damages and on the assembly and stability of www.elsevier.com/locate/ccr