The synthesis of potent marcocyclic reni
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Daljit S. Dhanoa; William H. Parsons; William J. Greenlee; Arthur A. Patchett
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Article
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1992
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Elsevier Science
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French
β 319 KB
## An eflcient synthesis of a novel class of potent macrocyclic renin inhibitors exemplified by compounds 1 and 2, which involves the macrocvclization of 8 to 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and2 disclosed here incorporates (2R,3S)-3-a&o-&yclohe~l-2-hydr