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Lactonization of GD1b ganglioside under acidic conditions

✍ Scribed by Rosaria Bassi; Laura Riboni; Sandro Sonnino; Guido Tettamanti

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
387 KB
Volume
193
Category
Article
ISSN
0008-6215

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✦ Synopsis

ABSTRACX Gangliosides that contain the disialosyl residue a-NeuSAc-(2-+8)-a-NeuSAc-(2+3)-can lactonize in the presence of traces of acid and this reaction has been studied in detail on GDlb {~-Gal-(1+3)-/3-GalNAc-(l-+4)-[cY-NeuSAc-(2-+8)-~-NeuSAc-(2+3)]+Gal-( l-+4)-/3-Glc-(l-+1)-Cer}.

Lactonization occurs rapidly at a proton-ganglioside molar ratio of <l. At equilibrium, the ratio of GDlb to its lactone is 3:7. The data suggest the possibility that a proton-driven lactonization of gangliosides may occur in vivo.

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