intact human platelets bind cytochalasin B (CB) with a capacity of 100-120 p mols CBimg protein or approximately 7 x lo4 rnoleculeslcell and dissociation constants (KD) ranging from 2 x 10" to lo6 M. Up to 85% of this saturable binding is displaced by 'lo+ M cytochalasin E (CE). This CE-sensitive bi
Lactoferrin binding to human platelets
โ Scribed by Ana Maneva; Borislava Taleva; Vladi Manev; Ljuben Sirakov
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 440 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0020-711X
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The binding of cytochalasin B (CB) to human platelets and to isolated platelet cytosol and membranes has been analyzed with [3H]CB. High-and low affinity classes of saturable binding sites were associated with intact platelets. Binding at very low concentrations of CB (i.e., high-affinity binding) w