Genetic anticipation, a phenomenon characterized by increased severity of symptoms and earlier age at onset of a disease in successive generations, is believed to be present in schizophrenia. In several neurodegenerative diseases showing anticipation, the mutation causing the disease is an expanded
Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21
β Scribed by Antonarakis, Stylianos E.; Blouin, Jean-Louis; Lasseter, Virginia K.; Gehrig, Corinne; Radhakrishna, Uppala; Nestadt, Gerry; Housman, David E.; Kazazian, Haig H.; Kalman, Katalin; Gutman, George; Fantino, Emmanuel; Chandy, K. George; Gargus, J. Jay; Pulver, Ann E.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 15 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19990820)88:4<348::aid-ajmg11>3.0.co;2-n
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12-q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1-q13.1. We therefore investi
Possible involvement of receptors in the pathogenesis of schizophrenia has been suggested. In this study we searched systematically for polymorphisms in the 5-franking region of the 1 receptor. Genetic variation in this region could reduce the expression of the gene, and this suggestion is compatibl
Potential contributions of dopamine transporter (DAT) gene variants to delusional disorder were investigated using association analysis. DAT gene VNTR polymorphisms were assessed in 61 delusional patients and 54 normal controls. No differences were found in either genotypic or allelic distributions.
Genetic epidemiology has provided consistent evidence over many years that schizophrenia has a genetic component, and that this genetic component is complex, polygenic, and involves epistatic interaction between loci. Molecular genetics studies have, however, so far failed to identify any DNA varian
Recent findings of an association between schizophrenia and a T102C polymorphism at the 5-HT 2a receptor gene (particularly with genotype 1-2 and 2-2 and allele 2) prompted us to investigate this marker in familial Irish schizophrenic patients, their relatives, and ethnically matched unrelated contr