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14-3-3 protein ? chain gene (YWHAH) polymorphism and its genetic association with schizophrenia

✍ Scribed by Toyooka, Kazuhiko; Muratake, Tatsuyuki; Tanaka, Toshihisa; Igarashi, Shuichi; Watanabe, Hiromi; Takeuchi, Hiromori; Hayashi, Shigenobu; Maeda, Masaya; Takahashi, Makoto; Tsuji, Shoji; Kumanishi, Toshiro; Takahashi, Yasuo

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 17 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990416)88:2<164::aid-ajmg13>3.0.co;2-3

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✦ Synopsis

Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12-q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1-q13.1. We therefore investigated allele frequencies of a variable number of tandem repeat (VNTR) in the 5-noncoding region of the 14-3-3 chain gene in controls and schizophrenics. The frequencies of the two-repeat allele were significantly higher (P < 0.05) in the schizophrenics, and particularly in those with onset before age 22 (early-onset schizophrenics, P < 0.02), than in the controls. The odds ratio was significantly increased in the early-onset schizophrenics homozygous for the two-repeat allele (OR = 3.3, 95% CI = 1.1-9.7). The 14-3-3 chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia.

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