✦ LIBER ✦

Lack of evidence for maternal effect in familial Alzheimer's disease

✍ Scribed by Dr. Haydeh Payami; Kristen Hoffbuhr

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 240 KB
Volume: 10
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370100622

No coin nor oath required. For personal study only.

✦ Synopsis

Mitochondria1 defects may be involved in Alzheimer's disease (AD) by lowering the oxidative phosphorylation efficiency at an earlier age. To investigate the possible contribution of an inherited mitochondrial DNA defect to familial AD (FAD), we examined the Genetic Analysis Workshop (GAW) data for evidence of maternal transmission and the effect on the age of onset. We found no evidence in support of inherited mitochondrial defects in the GAW FAD kindreds.

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