## Abstract The effect of the apolipoprotein E (APOE) ฯต4 allele on age of onset was analyzed in two groups of families with earlyโonset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) earlyโonset nonโVG families showing evidence of linkage
Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease
โ Scribed by Dr Sandro Sorbi; Benedetta Nacmias; Paolo Forleo; Silvia Piacentini; Stefania Latorraca; Luigi Amaducci
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 389 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
โฆ Synopsis
seen at our Stroke Service and Stroke Clinic so as to minimize bias of nonrandom sampling. We attempted to obtain routinely many of the laboratory tests that may be abnormal in association with aCL; however, every patient did not have every study performed routinely.
We conclude that a larger, controlled, prospective study of recurrent stroke and thrombo-occlusive event risk attributable to aPL is warranted. The recently initiated collaboration of the Warfarin Aspirin Recurrent Stroke Study (WARSS) and the Antiphospholipid Antibodies and Stroke Study (APASS) groups should provide these data. 15. Rosove MH, Brewer PMC. Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann
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Background. Anticholinesterase therapies oer modest beneยฎt to subgroups of AD suerers. However, there has previously been no way of predicting which patients will respond to any of the drugs. Objective. To discover if gender and/or apolipoprotein E genotype can be used as predictors of response in