Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation
β Scribed by Iida, M; Towatari, M; Nakao, A; Iida, H; Kiyoi, H; Nakano, Y; Tanimoto, M; Saito, H; Naoe, T
- Book ID
- 110054163
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 107 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of AN
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