✦ LIBER ✦

Lack of Complement-Dependent Cytolytic Antibodies in Hepatitis A Virus Infection

✍ Scribed by Peter Gabriel; Dr. Angelika Vallbracht; Bertram Flehmig

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 460 KB
Volume: 20
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890200105

No coin nor oath required. For personal study only.

✦ Synopsis

Sera collected from patients with acute hepatitis A virus (HAV) infection and convalescent sera were examined for cytolytic activity against HAV-infected human-embryo lung fibroblasts (HAV carrier fibroblasts). Using the 51chromium release assay, no complement dependent antibody mediated cytolytic activity against HAV carrier cells could be detected. In control experiments with identical cell strains, anti-herpes simplex virus (HSV) positive sera and complement caused specific lysis of HSV type 1 infected target cells. The data presented here do not support the hypothesis that in the possible immunopathogenesis of HAV infection, complement-dependent cytolytic antibodies play an essential role.

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