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Lack of competition of substrates for P-glycoprotein in MCF-7 breast cancer cells overexpressing MDR1

โœ Scribed by Jennifer G Hall; Ann H Cory; Joseph G Cory

Book ID
117259417
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
165 KB
Volume
39
Category
Article
ISSN
0065-2571

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The drug transporter P-glycoprotein (P-gp) appears to play an important role in the ability of tumor cells to evade killing by chemotherapeutic agents. Using pharmacological inhibitors of cAMP-dependent protein kinase (PKA), it has been suggested that, similar to rodent model systems, the human P-gp