Lack of checkpoint control in human pluripotent stem cells: a cause for genomic instability?
β Scribed by G. Ambartsumyan; D. Conway; J. Vincent; A. Clark
- Book ID
- 116478018
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 34 KB
- Volume
- 94
- Category
- Article
- ISSN
- 1556-5653
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## Abstract Rapid selfβrenewal of human embryonic stem (ES) cells (NIH designation WA01 and WA09) is accommodated by an abbreviated cell cycle due to a reduction in the G1 phase. Thus, molecular mechanisms operative in ES cells may expedite the cellular commitment to progress into S phase to initia
## Background Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a number of neural pathologies including smaller brain size, reduced numbers of neurons, reduced dendritic spin