Lack of BCR/ABL rearrangement in acute and chronic T cell leukemias
✍ Scribed by Simões, B P; Scaffo, M H S; Falcão, R P
- Book ID
- 110053611
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 59 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-6924
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## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis
of a de novo Ph in T-cell acute leukemia. So this case could be the first de novo T-cell childhood ALL showing the expression of p210 protein associated with a very aggressive clinical evolution.
Cytogenetic and molecular studies were performed on 20 interferon-␣ receiving Turkish chronic myelocytic leukemia patients. Four different restriction endonucleases and bcr-G probe were used for southern blot analysis to detect rearrangements of the bcr gene. The RT-PCR method was also applied to de