Inheritance of the apolipoprotein E E 4 allele is a risk factor for Alzheimer's disease (AD). A recent report studying Japanese patients suggested that a polymorphism of a trinucleotide repeat in the 5' untranslated region of an apolipoprotein E receptor, the very-low-density lipoprotein receptor, i
Lack of association of very low density lipoprotein receptor gene polymorphism with caucasian Alzheimer's disease
β Scribed by Kaoru Okuizumi; Osamu Onodera; Hajime Tanaka; Dr Shoji Tsuji; Koji Seki; Yoshio Namba; Kazuhiko Ikeda; Ann M. Saunders; Margaret A. Pericak-Vance; Allen D. Roses
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 366 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0364-5134
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β¦ Synopsis
atrophy (SMA) type I1 and 111 in the same sibship are not caused by different alleles at the SMA locus on 5q. Am J Hum
π SIMILAR VOLUMES
The -4 allele of apolipoprotein E (APOE) is associated with increased risk of Alzheimer's disease (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5 untranslated region of the very low-density lipoprotein receptor (VLDL-R) gene, a receptor for ap
## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.
It is now commonly known that possession of one of the three common alleles of the apolipoprotein E (APOE) gene (allele epsilon 4) confers an increased risk for both familial and sporadic Alzheimer's disease (AD), and that this risk is dose-dependent. Other genes that may play a role in AD, either t