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Lack of association of trinucleotide repeat polymorphisms in the very-low-density lipoprotein receptor gene with Alzhelner's disease

✍ Scribed by Haeyong Chung Ba; Carol T. Roberts; Steven Greenberg; G. William Rebeck; Richard Christie Bs; Robert Wallace; Howard J. Jacob; Dr Bradley T. Hyman

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
440 KB
Volume
39
Category
Article
ISSN
0364-5134

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✦ Synopsis

Inheritance of the apolipoprotein E E 4 allele is a risk factor for Alzheimer's disease (AD). A recent report studying Japanese patients suggested that a polymorphism of a trinucleotide repeat in the 5' untranslated region of an apolipoprotein E receptor, the very-low-density lipoprotein receptor, is genetically associated with AD, with overrepresentation of the allele containing five copies of the repeat. We determined the allele frequencies of the verylow-density lipoprotein receptor in 3 white populations totaling 469 individuals. In contrast to the previous report, we found no differences in allele frequencies between case patients and control subjects. The discrepancy could be due to differences in Japanese and white populations. Nonetheless, these data weaken the likelihood that this polymorphism in the very-low-density lipoprotein receptor gene is strongly associated with AD.

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