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Lack of association between obsessive-compulsive disorder and the dopamine D3 receptor gene: Some preliminary considerations

✍ Scribed by Catalano, Marco ;Sciuto, Gabriella ;Di Bella, Daniela ;Novelli, Emanuela ;Nobile, Maria ;Bellodi, Laura

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 355 KB
Volume: 54
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320540312

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✦ Synopsis

Controversial results possibly suggesting an association between Tourette's Syndrome (TS) and excess of homozygosity at a Msc I polymorphism in the Dopamine D3 receptor (DRD,) gene have recently been reported. Since a relationship between Obsessive-Compulsive Disorder (OCD) and Tourette's Syndrome (TS) has been suggested, in this study we assessed the frequency of this 2-allele polymorphism in a sample of 97 OCD patients and in 97 control subjects. No statistically significant differences in allele or genotype frequencies were found. Thus this mutation in the coding sequence of the DRD3 gene is unlikely to confer susceptibility to OCD. @

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