## Abstract **BACKGROUND:** Nonsyndromic cleft lip with or without cleft palate (NCL/P) is a common structural malformation with a complex and multifactorial etiology. It has been shown that maternal psychological stress in the periconceptional period can contribute to an increase in the risk of NC
Lack of association between common polymorphisms of epidermal growth factor receptors and nonsyndromic cleft lip with or without cleft palate
โ Scribed by M. Martinelli; L. Scapoli; F. Pezzetti; G. Spinelli; S. Lunardi; F. Carinci
- Book ID
- 116565201
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 87 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0165-5876
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## Objectives/Hypothesis: Interferon regulatory factor 6 (__IRF6__), the gene that causes van der Woude syndrome (VWS), is a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCLP) because a number of studies have supported an association between NSCLP and single
Cleft lip with or without cleft palate (CL +/- P) is the most frequent craniofacial malformation in different human populations and its cause is largely unknown. Several studies based on population associations have suggested that an allele mapping in the transforming growth factor alpha locus could