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Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample

✍ Scribed by Mateo, Ignacio ;Sánchez-Guerra, Marisa ;Combarros, Onofre ;Llorca, Javier ;Infante, Jon ;González-García, Javier ;del Molino, Jesús Pérez ;Berciano, José


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
77 KB
Volume
114
Category
Article
ISSN
0148-7299

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## Abstract Alzheimer's disease (AD) is characterized by an extensive loss of cholinergic neurons, and their cortical projections, from the basal forebrain area. The resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ACh), decrease