## Abstract 2′‐Amino‐4′ ‐fluoro‐4‐(4‐hydroxy‐4‐) (3‐trifluoromethylphenyl) ‐ piperidino‐2‐^14^Cbutyrophenone [ID‐4708‐ (piperidine‐^14^C]), a neuroleptic agent, was synthesized for use in metabolic studies. The synthesis was achieved by the reaction scheme shown in Fig. 1. 1‐Benzyl‐4‐piperidone‐2‐^
Labelling of neuroleptic butyrophenones. II. Synthesis of 2′amino-4′-fluoro-4-[4-hydroxy-4-(3-trifluoromethylpfenyl)piperidino]butyrophenone-(carbonyl-14C)
✍ Scribed by Iwao Nakatsuka; Kazuo Kawahara; Takeshi Kamada; Akira Yoshitake
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- French
- Weight
- 322 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Mepindolol, a potent ß‐adrenoceptor blocking agent, was labelled with ^14^C by two different routes yielding the 2‐[^14^C]methyl and [2‐^14^C] products. While the first alternative was abandoned because of low overall yield, the latter route provided mepindolol with a specific activity
## Abstract Carbon‐14 labeled (__R__)‐3‐fluoro‐4‐(2′‐(5′′, 6′′, 7′′, 8′′‐tetrahydro‐5′′, 5′′, 8′′, 8′′‐tetramethyl‐2′′‐naphthyl)‐[2′‐hydroxy‐^14^C])[carbonyl‐^14^C]acetamidobenzoic acid, **1**, was prepared in a six step radioactive synthesis from diethyl [carboxylate‐^14^C~1,2~] oxalate. The penul
14C-Labelled 6-hydroxy-5,7-dimethyl-2-(methylamino)-4-(3-pyridylmethyl)benzothiazole dihydrochloride (14C-E3040 dihydrochloride), required for a study of the phrmacokinetic profile of E3040, a novel dual inhibitor of 5-lipoxygenase and thromboxane A2 synthetase, was synthesized in one step using [2-
## Abstract The title compound (1) was synthesized by a 7‐step sequence. 4‐Amino‐2‐hydroxy‐[carbonyl‐^14^C]benzoic acid (1) was selectively methylated to provide the ether ester 2, which was smoothly chlorinated in acetic acid to give 3. The ester was hydrolyzed with aqueous potassium hydroxide to