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Labelling of antibiotic peptide - edeine B with 14C

✍ Scribed by Janina Z̀upańska; Jadwiga Wasowicz; Kazimierz Dziegielewski

Book ID: 102371662
Publisher: John Wiley and Sons
Year: 1978
Tongue: French
Weight: 253 KB
Volume: 15
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580150112

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✦ Synopsis

Edeine B with guanyl group labelled with 14C y . 8 obtained by treating edeine A with a 6-fold exoeae of O-a~ethylisourea-~~C. The radioohemioal yield m a loll$. The produot was purified on a oolumn, filled with Sephadex LH 20 and by preparative paper ohromatography. The radioohemioal purity of the obtained preparation wms 97.75. Edeine B is one of the oomponents of the edeine oopplex, oompounds of the antibiotio peptide s o u p /1,2/. These oompounds exhibit two-direotional aotiont baoteriostatio on one hand, stimulating in FWA syntheaia and inhibitin6 in DNA 8ynthesia /3-5/, on the other hand. Owing to its biologioal aotivity edeine B ia uaed in the atudies of ba8io life prooe8aea. Labelling it with 14C make8 possible applioation of isotope teohaiquets.

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