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Labeling of monoclonal antibodies with a67Ga-phenolic aminocarboxylic acid chelate

✍ Scribed by Siegfried Matzku; Jochen Schuhmacher; Henning Kirchgeßner; Josef Brüggen


Book ID
104683017
Publisher
Springer
Year
1986
Tongue
English
Weight
833 KB
Volume
12
Category
Article
ISSN
0340-6997

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Optimum labelling of monoclonal antibody
✍ R. R. Reilly; G. G. Ege 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 379 KB

Monoclonal antibody 3E1.2 was coupled with the bifunctional chelate, cyclic DTPA anhydride, at molar ratios (cOTPAA:3E1.2) of 1:1, lO:l, 1OO:l and 1oOO:l. The desired substitution level of less than one mol of D"PA/bl of 3E1.2 was achieved at a molar ratio of 1O:l and a coupling efficiency of 9.9t3.