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Labeling of monoclonal antibodies with a67Ga-phenolic aminocarboxylic acid chelate

✍ Scribed by Jochen Schuhmacher; Ronald Matys; Harald Hauser; Wolfgang Maier-Borst; Siegfried Matzku


Book ID
104683016
Publisher
Springer
Year
1986
Tongue
English
Weight
822 KB
Volume
12
Category
Article
ISSN
0340-6997

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Optimum labelling of monoclonal antibody
✍ R. R. Reilly; G. G. Ege πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 French βš– 379 KB

Monoclonal antibody 3E1.2 was coupled with the bifunctional chelate, cyclic DTPA anhydride, at molar ratios (cOTPAA:3E1.2) of 1:1, lO:l, 1OO:l and 1oOO:l. The desired substitution level of less than one mol of D"PA/bl of 3E1.2 was achieved at a molar ratio of 1O:l and a coupling efficiency of 9.9t3.