✦ LIBER ✦

Labeling index in squamous cell carcinoma of the larynx

✍ Scribed by Dr. Manuela Balzi; Dr. Benedetta M. Ninu; Dr. Aldo Becciolini; Dr. Elena Scubla; Dr. Patrizia Boanini; Dr. Ezio Gallina; Dr. Oreste Gallo; Dr. Omero Fini-Storchi; Dr. Roberto Bondi

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 376 KB
Volume: 13
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880130413

No coin nor oath required. For personal study only.

✦ Synopsis

Two cell kinetic parameters, the 3H-thymidine labeling index (TLI) and the mitotic index (MI), were studied in vitro on fragments of squamous cell carcinoma tissue of the larynx. They were evaluated to identify those elements able to characterize the growth of these solid tumors. The values of these parameters were analyzed as a function of the clinical stage and the involvement of the regional lymph nodes. Results showed a statistically significant increase in the TLI from stage ll to T3. No statistically significant differences in the TLI values were observed between the patients with positive and negative lymph nodes. HEAD & NECK 1991;13:344-348 As yet, no reliable histomorphologic or biochemical parameters have been determined which, based on tumor growth and its correlation to clinical data, can be used safely in therapeutic planning to improve prognosis.

The proliferative rate of tumors is subject to a marked variability due to intrinsic characteristics, such as cell cycle time, growth fraction, cell loss, and degree of differentiation. Tumor growth

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