L-dopa and cerebrospinal fluid homovanillic acid in parkinsonism
โ Scribed by W. Weiner; W. Harrison; H. Klawans
- Book ID
- 118934863
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- English
- Weight
- 186 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0024-3205
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Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism. RDP has been reported by our group in two apparently unrelated families. We now report analysis of cerebrospinal fluid metabolites of dopamine, norepineph
We report a 3-month-old female with infantile spasms that responded transiently to pyridoxine and permanently to oral L-dopa. Initial CSF levels of homovanillic acid were low, suggesting disturbed turnover of dopamine. These findings suggest that disturbed brain monoamine metabolism may be causally