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Unresponsiveness to l-DOPA in parkinsonian patients: a study of homovanillic acid concentration in the cerebrospinal fluid

✍ Scribed by Katsunori Nishi; Tomoyoshi Kondo; Hirotaro Narabayashi; Hideki Takubo; Shonosuke Muramoto; Hirotake Araki


Book ID
118930828
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
345 KB
Volume
92
Category
Article
ISSN
0022-510X

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A patient with infantile spasms and low
✍ H. Sugie; Y. Sugie; N. Kato; Y. Fukuyama πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 221 KB

We report a 3-month-old female with infantile spasms that responded transiently to pyridoxine and permanently to oral L-dopa. Initial CSF levels of homovanillic acid were low, suggesting disturbed turnover of dopamine. These findings suggest that disturbed brain monoamine metabolism may be causally