## Abstract A novel assay for the determination of lโasparaginase activity in human plasma is described that is based on the HPLC quantitation of lโaspartic acid produced during enzyme incubation. Methods for monitoring lโasparagine depletion are also described. Chromatography of lโaspartic acid, l
โฆ LIBER โฆ
l-Asparagine depletion levels andl-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment
โ Scribed by Masahito Tsurusawa; Motoaki Chin; Asayuki Iwai; Keiko Nomura; Hideaki Maeba; Takashi Taga; Takeshi Higa; Tomoko Kuno; Toshinori Hori; Akiko Muto; Miyo Yamagata
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 242 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Thrombotic events (TEs) are serious secondary complications in children with acute lymphoblastic leukemia (ALL) who receive Lโasparaginase (ASP) therapy; however, the prevalence of TEs has not been established. The primary objective of the Prophylactic Antithrombin Replac