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KRAS and BRAF mutations in sinonasal cancer

✍ Scribed by Fernando López; Cristina García Inclán; Jhudit Pérez-Escuredo; César Álvarez Marcos; Bartolomé Scola; Carlos Suárez; José Luis Llorente; Mario A. Hermsen

Book ID
119339220
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
460 KB
Volume
48
Category
Article
ISSN
1368-8375

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## Abstract Constitutive activation of the kinase cascade involving __RAS__, __RAF__, __MEK__ and __ERK__ is common to human cancers, and mutations of __KRAS__ and __BRAF__ are mutually exclusive and serve as alternatives to activate the RAS/RAF/ERK signaling pathway. __RAS__ mutations are known to