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KRAS and BRAF mutations in prostate carcinomas of Chinese patients

✍ Scribed by Yanying Shen; Yachao Lu; Xiaolu Yin; Guanshan Zhu; Jianshan Zhu

Book ID
113513690
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
234 KB
Volume
198
Category
Article
ISSN
0165-4608

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## Abstract Constitutive activation of the kinase cascade involving __RAS__, __RAF__, __MEK__ and __ERK__ is common to human cancers, and mutations of __KRAS__ and __BRAF__ are mutually exclusive and serve as alternatives to activate the RAS/RAF/ERK signaling pathway. __RAS__ mutations are known to