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Detection of KRAS and BRAF Mutations in Colorectal Carcinoma

✍ Scribed by Arcila, Maria; Lau, Christopher; Nafa, Khedoudja; Ladanyi, Marc


Book ID
122817934
Publisher
American Society for Investigative Pathology
Year
2011
Tongue
English
Weight
927 KB
Volume
13
Category
Article
ISSN
1525-1578

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## Abstract Mutational analysis of __KRAS__ codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti‐EGFR therapies. However, even among patients whose tumors are wildtype for __KRAS__ codons 12 and 13, only a subse