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Knockdown of Caveolin-1 by Antisense Oligonucleotides Impairs Angiogenesis in Vitro and in Vivo

✍ Scribed by Cristiana Griffoni; Enzo Spisni; Spartaco Santi; Massimo Riccio; Tiziana Guarnieri; Vittorio Tomasi


Book ID
115586564
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
246 KB
Volume
276
Category
Article
ISSN
0006-291X

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## Abstract The expression of MRP1 (multidrug resistance protein‐1) is associated with chemoresistance and poor prognosis in neuroblastoma. MRP1 antisense oligonucleotides were used in an __in vivo__ mouse‐human xenograft model of neuroblastoma to downregulate MRP1. The MRP1 ASO reduced protein lev