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Specific Inhibition of Oncogene Expression in Vitro and in Vivo by Antisense Oligonucleotides

โœ Scribed by LEN NECKERS; ANGELO ROSOLEN; BRIGID FAHMY; LUKE WHITESELL


Book ID
119866937
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
566 KB
Volume
660
Category
Article
ISSN
0890-6564

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The promoter region of the c-fos oncogene 5' flanking sequence contains enhancer elements crucial for binding nuclear factors that regulate transcription following cell proliferation and differentiation. Single-stranded deoxyoligonucleotides were chosen for modulation of c-fos protooncogene expressi