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Inhibition of angiogenesis in vitro by αv integrin–directed antisense oligonucleotides

✍ Scribed by Kronenwett, Ralf; Gräf, Thorsten; Nedbal, Wolfgang; Weber, Markus; Steidl, Ulrich; Rohr, Ulrich-Peter; Möhler, Thomas; Haas, Rainer


Book ID
110018908
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
604 KB
Volume
9
Category
Article
ISSN
0929-1903

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This study was performed to determine whether a highly selective nonpeptide ␣ v ␤ 3 antagonist (SH306) would prove effective in inhibiting neointima formation in a rabbit cuff model. The animals were dosed with SH306, 5 mg/kg i.v., followed by 10 mg/kg s.c., 3 times daily for 3 days, or with vehicle