✍ Scribed by H. Dougan; D. M. Lyster; J. S. Vincent; T. Rihela
No coin nor oath required. For personal study only.
We have examined the labelling of [1231] HIBG by a Cu(1) catalyzed reaction in aqueous solution. We regularly obtained >99% radiochemical purity [1231] MIBG product and >97% radiochemical yield. At 100°C with 2 mg MIBG the radiochemical purity reached 85% at 2.5 Pin, 97% at 5 min and 99% at 10 Pin through 30 min. proceeded at roughly one tenth the former speed. Many details of technique were essential; reagents and the use of II2SO4 solvent. Neglect of proper procedure led to low radiochemical yields and 1231 bound to apparatus. The procedure has been utilized with up to 1.0 mL 1 2 3 1 (0.1N NaOB) or 93 d i 1231. A study of temperature dependence showed that the reaction proceeded readily, albeit more slowly at 20°C. The temperature coefficient at 100°C was estimated -1.7. With 200 Ug MIBG the reaction the highlights were use of dry triturated
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