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KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance

✍ Scribed by Zhu, M-J; Ou, W-B; Fletcher, C D M; Cohen, P S; Demetri, G D; Fletcher, J A

Book ID
110072460
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
564 KB
Volume
26
Category
Article
ISSN
0950-9232

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## Abstract Mutations of proto‐oncogene c‐KIT in gastrointestinal stromal tumors (GISTs) are considered to cause a constitutive activation of KIT responsible for their oncogenesis. Imatinib has therapeutic potential for GISTs because of its inhibitory effect on KIT kinase activity. To investigate t