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Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter "RASCAL" Study

✍ Scribed by Andreyev, H. J. N.; Norman, A. R.; Clarke, P. A.; Cunningham, D.; Oates, J. R.


Book ID
127173444
Publisher
Oxford University Press
Year
1998
Tongue
English
Weight
99 KB
Volume
90
Category
Article
ISSN
0027-8874

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Mutant-enriched PCR was applied to the detection of mutations at codons I 2 and I 3 of K-ras genes in the stools of patients with colorectal cancer. Mutations were analyzed in stool samples obtained prior to surgery. Resected tumor specimens were screened for K-ras mutations by PCR-mediated RFLP ana