Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells
β Scribed by Milena Salerno; Arlette Garnier-Suillerot
- Book ID
- 114013932
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 123 KB
- Volume
- 421
- Category
- Article
- ISSN
- 0014-2999
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π SIMILAR VOLUMES
Resistance to chemotherapy is intrinsically present in most nonsmall-cell lung carcinomas (NSCLC). No parameter has yet been determined to predict the response to chemotherapy. However, MRP1 (multidrug resistance-associated protein) is suspected to play an important role in resistance to treatment.
Human non-small-cell lung cancer (NSCLC) is considered to be a chemotherapy-refractory malignancy. The underlying mechanisms remain rather obscure. The multidrug resistanceassociated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several dru