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Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein

โœ Scribed by Z. Benderra; A. Trussardi; H. Morjani; A.M. Villa; S.M. Doglia; M. Manfait


Book ID
117666933
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
413 KB
Volume
36
Category
Article
ISSN
0959-8049

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Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-