Expression of the multidrug resistance-associated protein gene in nom-small cell lung cancer
โ Scribed by Li, J.H; Xu, M; Xie, J.M
- Book ID
- 118570228
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 116 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0169-5002
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๐ SIMILAR VOLUMES
Human non-small-cell lung cancer (NSCLC) is considered to be a chemotherapy-refractory malignancy. The underlying mechanisms remain rather obscure. The multidrug resistanceassociated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several dru
MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expres- sion of M R P mRNA in multidrug-resistant KB sublines (KB-8-5, KB-CZ, C -W and C A I to), human non-small-cell lung carcinomas (NSC