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Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas

✍ Scribed by Yutaka Chuman; Tomoyuki Sumizawa; Yuji Takebayashi; Kiyoshi Niwa; Kazutaka Yamada; Misako Haraguchi; Tatsuhiko Furukawa; Shin-ichi Akiyama; Takashi Aikou

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
720 KB
Volume
66
Category
Article
ISSN
0020-7136

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✦ Synopsis

MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expres- sion of M R P mRNA in multidrug-resistant KB sublines (KB-8-5, KB-CZ, C -W and C A I to), human non-small-cell lung carcinomas (NSCLC), gastric and colorectal carcinomas, and compared it with that in drug-sensitive human KB cells. MRP gene expression was elevated in 8 of 9 (8%) squamous-cell carcinomas of the lung. Furthermore, MRP expression in 4 squamouscell carcinomas (L13, 18, 19 and 20) was more than 3.6 times higher than in KB-3-1 cells, and the average MRP mRNA expression level of all squamous-cell carcinomas was significantly higher than that of adenocarcinoma of the lung and of colorectal and gastric carcinomas. These results suggested that the M R P is responsible, at least in part, for drug resistance in some squamous-cell carcinomas of the lung.

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