Kinetics for Hybridization of Peptide Nucleic Acids (PNA) with DNA and RNA Studied with the BIAcore Technique †
✍ Scribed by Jensen, Kristine Kilså; Ørum, Henrik; Nielsen, Peter E.; Nordén, Bengt
- Book ID
- 120316170
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 174 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0006-2960
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## Abstract A new series of oxy‐peptide nucleic acids (pyrrolidine‐based oxy‐peptide nucleic acids = POPNAs) of four different stereoisomeric forms (__cis__‐L, __cis__‐D, __trans__‐L, __trans__‐D) have been synthesized. To find a favorable stereoisomer of POPNA for hybridization with DNA or RNA, th
A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH 2 ) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duple