✦ LIBER ✦
In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA
✍ Scribed by Raman Vysabhattar; Krishna N. Ganesh
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 511 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH 2 ) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes.