Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA
โ Scribed by Fader, Lee D.; Boyd, Michael; Tsantrizos, Youla S.
- Book ID
- 126866351
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 108 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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## Abstract A new series of oxyโpeptide nucleic acids (pyrrolidineโbased oxyโpeptide nucleic acids = POPNAs) of four different stereoisomeric forms (__cis__โL, __cis__โD, __trans__โL, __trans__โD) have been synthesized. To find a favorable stereoisomer of POPNA for hybridization with DNA or RNA, th
A new pyrrolidinyl peptide nucleic acid (PNA) comprising of an alternate sequence of 4 0 -nucleobasemodified proline with (2 0 R,4 0 S) configuration and a (1S,2S)-2-aminocyclopentanecarboxylic acid [(2 0 R,4 0 S)-acpcPNA] backbone was synthesized and its DNA-, RNA-and self-pairing properties studie