Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: A reevaluation
β Scribed by Antonio Cipiciani; Cynthia Ebert; Paolo Linda; Fulvio Rubessa; Gianfranco Savelli
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 205 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
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β¦ Synopsis
The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25 degrees. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.
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