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Kinetics and mechanism of the basic hydrolysis of indomethacin and related compounds: A reevaluation

✍ Scribed by Antonio Cipiciani; Cynthia Ebert; Paolo Linda; Fulvio Rubessa; Gianfranco Savelli


Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
205 KB
Volume
72
Category
Article
ISSN
0022-3549

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✦ Synopsis


The kinetics of the hydrolysis of indomethacin and related compounds were studied in an alkaline medium at 25 degrees. The pseudo-first-order rate constants were evaluated from log absorbance versus time plots in the ultraviolet. These compounds showed a second-order rate constant at low concentrations of hydroxide ion and a first-order rate constant at higher concentrations of hydroxide ion.


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