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Kinetic resolution of trans-2-acetoxycycloalkan-1-ols by lipase-catalysed enantiomerically selective acylation

✍ Scribed by Viktória Bódai; Olivér Orovecz; György Szakács; Lajos Novák; László Poppe

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
215 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

Kinetic resolution of a series of racemic trans-cycloalkane-1,2-diol monoacetates rac-2a-d was performed by enantiomerically selective transesterification with vinyl acetate catalysed by commercial and our own-prepared fungal lipases to yield diacetates (R,R)-3a-d and monoacetates (S,S)-2a-d in high enantiomeric purity. The monoacetates (R,R)-2a-d were also prepared from the racemic diacetates rac-3a-d by lipase-catalysed hydrolysis.

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