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Kinetic Resolution of (R,S)-2-Butanol Using Enzymatic Synthesis of Esters

✍ Scribed by Maria Dolores Romero; Jose Maria Gomez; Beatriz Diaz-Suelto; Alicia Garcia-Sanz; Nicola Baster


Book ID
107565975
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
245 KB
Volume
165
Category
Article
ISSN
0273-2289

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✍ Andreas Wallner; Harald Mang; Silvia M. Glueck; Andreas Steinreiber; Sandra F. M πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 214 KB

A single enantiomer of a (stereo)chemically labile allylic-homoallylic alcohol was obtained in 91% e.e. and 96% yield from the racemate by employing a lipase-catalysed kinetic resolution coupled to in situ inversion under carefully controlled (Mitsunobu) conditions in order to suppress side reaction