Chemo-enzymatic synthesis of chiral cyclic compounds: Efficient kinetic resolution of 2-bromo-2-cyclohexenol
✍ Scribed by Pedro Noheda; Germán García; M. Carmen Pozuelo; Bernardo Herradón
- Book ID
- 103977650
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 272 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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## Abstract The first non‐enzymatic method for the asymmetric acylation of β‐hydroxy sulfides using a chiral diamine derived from (S)‐proline as catalyst is developed.
A novel and efficient synthesis of enantiomerically pure αdibenzylamino αЈ-sulfinyl ketones starting from a mixture of both epimers of α-bromo αЈ-(R)-sulfinyl ketone has been realized through combined in situ substitution-epimerization in a so-called Dynamic Kinetic Resolution (DKR). The scope of th
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